Hair Loss in Men

Hair Loss in Men

Common cause of hair loss in men is Androgenetica Alopecia, also known as Male Pattern Baldness.

It affects over 50% of male population over forty years of age.

It is caused by DHT hormone action on genetically predisposed hair follicles of the scalp.  It reduces anagen phase of hair growth and progressively reduces hair follicles which over time leads to hair loss.  It follows a pattern of receding hairline and hair thinning on the crown, as described by Norwood.  Follicle shrinks over time and eventually does not grow new hair.  The follicle remains alive indicating that there is a possibility to grow new hair.
Most commonly seen pattern of male baldness starts with receding hair line, and forming of an “M” shape. Further hair loss leads to U-shaped pattern of hair.

3 Independent factors that affect Androgenetica Alopecia:

  1. Genetic Predisposition
    Even after extensive research, genes responsible for male pattern baldness are not 100% isolated.  Gene expression depends on many factors, most importantly hormonal balance or imbalance and age, and stress is also indentified as an important contributor to hair loss.  Unfortunately, genetic engineering that could possibly prevent hair loss is many years away.
  2. Hormones
    Enzyme 5 Alpha reductions exists in two forms: 5 Alpha R1 and 5 Alpha R2, with 5 Alpha R2 being predominant form involved in hair loss.  It plays important role in male pattern baldness.  It can be blocked by Finasteride, while both receptors can be blocked using Dutasteride.
  3. Age
    Presence of certain genes and hormonal conditions doesn’t always cause hair loss and age is an important factor in hair loss. Sensitive follicles must be continuously exposed to hormonal action after puberty to cause hair loss.  At what age hair loss might start depends on genetic predisposition and level of hormones acting on the follicle.  There are periods of slow and of rapid hair loss, as well as periods of steady hair production.  While many causes of hair loss are still unknown we do know for certain that hair volume and density diminish as we age.


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